Novel genomic island modifies DNA with 7-deazaguanine derivatives

The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ(0)) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was established...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Thiaville, Jennifer J., Kellner, Stefanie M., Yuan, Yifeng, Hutinet, Geoffrey, Thiaville, Patrick C., Jumpathong, Watthanachai, Mohapatra, Susovan, Brochier-Armanet, Celine, Letarov, Andrey V., Hillebrand, Roman, Malik, Chanchal K., Rizzo, Carmelo J., Dedon, Peter C., de Crécy-Lagard, Valérie
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801273/
https://ncbi.nlm.nih.gov/pubmed/26929322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518570113
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