7-Deazaguanine modifications protect phage DNA from host restriction systems

Genome modifications are central components of the continuous arms race between viruses and their hosts. The archaeosine base (G(+)), which was thought to be found only in archaeal tRNAs, was recently detected in genomic DNA of Enterobacteria phage 9g and was proposed to protect phage DNA from a wid...

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Publicado no:Nat Commun
Main Authors: Hutinet, Geoffrey, Kot, Witold, Cui, Liang, Hillebrand, Roman, Balamkundu, Seetharamsingh, Gnanakalai, Shanmugavel, Neelakandan, Ramesh, Carstens, Alexander B., Fa Lui, Chuan, Tremblay, Denise, Jacobs-Sera, Deborah, Sassanfar, Mandana, Lee, Yan-Jiun, Weigele, Peter, Moineau, Sylvain, Hatfull, Graham F., Dedon, Peter C., Hansen, Lars H., de Crécy-Lagard, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884629/
https://ncbi.nlm.nih.gov/pubmed/31784519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13384-y
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