Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

We report the most common single nucleotide substitution/deletion mutations in Favorable Histology Wilms Tumors (FHWT) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPG) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with...

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Publicado no:Cancer Cell
Main Authors: Walz, Amy L., Ooms, Ariadne, Gadd, Samantha, Gerhard, Daniela S., Smith, Malcolm A., Guidry Auvil, Jamie M., Meerzaman, Daoud, Chen, Qing-Rong, Hsu, Chih Hao, Yan, Chunhua, Nguyen, Cu, Hu, Ying, Bowlby, Reanne, Brooks, Denise, Ma, Yussanne, Mungall, Andrew J., Moore, Richard A., Schein, Jacqueline, Marra, Marco A., Huff, Vicki, Dome, Jeffrey S., Chi, Yueh-Yun, Mullighan, Charles G., Ma, Jing, Wheeler, David A., Hampton, Oliver A., Jafari, Nadereh, Ross, Nicole, Gastier-Foster, Julie M., Perlman, Elizabeth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800737/
https://ncbi.nlm.nih.gov/pubmed/25670082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.01.003
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