Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function

The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders. No change in function (loss or gain...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Aprile-Garcia, Fernando, Metzger, Michael W., Paez-Pereda, Marcelo, Stadler, Herbert, Acuña, Matías, Liberman, Ana C., Senin, Sergio A., Gerez, Juan, Hoijman, Esteban, Refojo, Damian, Mitkovski, Mišo, Panhuysen, Markus, Stühmer, Walter, Holsboer, Florian, Deussing, Jan M., Arzt, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795689/
https://ncbi.nlm.nih.gov/pubmed/26986975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151862
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