Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality

A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders. The P2X7R-Gln460Arg variant per se is not compromised in its function. However, heterologous expression...

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Vydáno v:J Neurosci
Hlavní autoři: Metzger, Michael W., Walser, Sandra M., Dedic, Nina, Aprile-Garcia, Fernando, Jakubcakova, Vladimira, Adamczyk, Marek, Webb, Katharine J., Uhr, Manfred, Refojo, Damian, Schmidt, Mathias V., Friess, Elisabeth, Steiger, Axel, Kimura, Mayumi, Chen, Alon, Holsboer, Florian, Arzt, Eduardo, Wurst, Wolfgang, Deussing, Jan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2017
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705750/
https://ncbi.nlm.nih.gov/pubmed/29079688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3487-16.2017
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