Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines.

We demonstrate that transfer of a yeast artificial chromosome (YAC) containing 230 kb of the human beta-globin locus into mouse erythroleukemia cells by fusion results in correct developmental regulation of the human beta-like globin genes. Additionally, we show that early after hybrid formation, hu...

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Autori principali: Peterson, K R, Zitnik, G, Huxley, C, Lowrey, C H, Gnirke, A, Leppig, K A, Papayannopoulou, T, Stamatoyannopoulos, G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC47951/
https://ncbi.nlm.nih.gov/pubmed/8248229
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