Network Analysis of the Chronic Hepatitis C Virome Defines Hypervariable Region 1 Evolutionary Phenotypes in the Context of Humoral Immune Responses

Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) comprises the first 27 N-terminal amino acid residues of E2. It is classically seen as the most heterogeneous region of the HCV genome. In this study, we assessed HVR1 evolution by using ultradeep pyrosequencing for a cohort of treatment-naive...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Palmer, Brendan A., Schmidt-Martin, Daniel, Dimitrova, Zoya, Skums, Pavel, Crosbie, Orla, Kenny-Walsh, Elizabeth, Fanning, Liam J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Genetic Diversity and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794698/
https://ncbi.nlm.nih.gov/pubmed/26719263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02995-15
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