Network Analysis of the Chronic Hepatitis C Virome Defines Hypervariable Region 1 Evolutionary Phenotypes in the Context of Humoral Immune Responses

Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) comprises the first 27 N-terminal amino acid residues of E2. It is classically seen as the most heterogeneous region of the HCV genome. In this study, we assessed HVR1 evolution by using ultradeep pyrosequencing for a cohort of treatment-naive...

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Vydáno v:J Virol
Hlavní autoři: Palmer, Brendan A., Schmidt-Martin, Daniel, Dimitrova, Zoya, Skums, Pavel, Crosbie, Orla, Kenny-Walsh, Elizabeth, Fanning, Liam J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794698/
https://ncbi.nlm.nih.gov/pubmed/26719263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02995-15
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