Network Analysis of the Chronic Hepatitis C Virome Defines Hypervariable Region 1 Evolutionary Phenotypes in the Context of Humoral Immune Responses

Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) comprises the first 27 N-terminal amino acid residues of E2. It is classically seen as the most heterogeneous region of the HCV genome. In this study, we assessed HVR1 evolution by using ultradeep pyrosequencing for a cohort of treatment-naive...

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Pubblicato in:J Virol
Autori principali: Palmer, Brendan A., Schmidt-Martin, Daniel, Dimitrova, Zoya, Skums, Pavel, Crosbie, Orla, Kenny-Walsh, Elizabeth, Fanning, Liam J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Genetic Diversity and Evolution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794698/
https://ncbi.nlm.nih.gov/pubmed/26719263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02995-15
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