Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer

Cancer cells use stress response pathways to sustain their pathogenic behavior. In breast cancer, stress response-associated phenotypes are mediated by the breast tumor kinase, Brk (PTK6), via the hypoxia-inducible factors HIF-1α and HIF-2α. Given that glucocorticoid receptor (GR) is highly expresse...

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Publicado en:Cancer Res
Autores principales: Anderson, Tarah M Regan, Ma, Shihong, Raj, Ganesh V, Cidlowski, John A, Helle, Taylor M, Knutson, Todd P, Krutilina, Raisa I, Seagroves, Tiffany N, Lange, Carol A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794366/
https://ncbi.nlm.nih.gov/pubmed/26825173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2510
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