Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4

The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70(S6K1) dependent phosphorylation of Pdcd4 followed by β-TrCP1-mediated ubiquitination, and prote...

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Udgivet i:PLoS One
Main Authors: Schmid, Tobias, Blees, Johanna S., Bajer, Magdalena M., Wild, Janine, Pescatori, Luca, Cuzzucoli Crucitti, Giuliana, Scipione, Luigi, Costi, Roberta, Henrich, Curtis J., Brüne, Bernhard, Colburn, Nancy H., Di Santo, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794182/
https://ncbi.nlm.nih.gov/pubmed/26982744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151643
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