Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S6K1)-dependent protein phosphorylation, β-TrCP1-me...

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書誌詳細
主要な著者: Blees, Johanna S., Bokesch, Heidi R., Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias, Brüne, Bernhard
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462793/
https://ncbi.nlm.nih.gov/pubmed/23056346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046567
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