Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S6K1)-dependent protein phosphorylation, β-TrCP1-me...

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Detalhes bibliográficos
Main Authors: Blees, Johanna S., Bokesch, Heidi R., Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias, Brüne, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462793/
https://ncbi.nlm.nih.gov/pubmed/23056346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046567
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