Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the Tumor Suppressor PDCD4

A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of...

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Detalhes bibliográficos
Main Authors: Grkovic, Tanja, Blees, Johanna S., Bayer, Magdalena M., Colburn, Nancy H., Thomas, Cheryl L., Henrich, Curtis J., Peach, Megan L., McMahon, James B., Schmid, Tobias, Gustafson, Kirk R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145332/
https://ncbi.nlm.nih.gov/pubmed/25196934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12084593
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