Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways

CLL remains an incurable disease in spite of the many new compounds being studied. Arsenic trioxide (ATO) induces apoptosis in all CLL cell types and could constitute an efficient therapy. To further explore this, we have studied the influence of stromal cells, key components of the CLL microenviron...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Amigo-Jiménez, Irene, Bailón, Elvira, Aguilera-Montilla, Noemí, Terol, María José, García-Marco, José A., García-Pardo, Angeles
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792595/
https://ncbi.nlm.nih.gov/pubmed/26540567
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