Cytokine secretion and NK cell activity in human ADAM17 deficiency

Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with a very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine secretion in response to LPS stimulation, correlating with the clinical picture of severe bacterem...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Tsukerman, Pinchas, Eisenstein, Eli M., Chavkin, Maor, Schmiedel, Dominik, Wong, Eitan, Werner, Marion, Yaacov, Barak, Averbuch, Diana, Molho-Pessach, Vered, Stepensky, Polina, Kaynan, Noa, Bar-On, Yotam, Seidel, Einat, Yamin, Rachel, Sagi, Irit, Elpeleg, Orly, Mandelboim, Ofer
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2015
Aiheet:
Research Paper: Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792548/
https://ncbi.nlm.nih.gov/pubmed/26683521
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