Cytokine secretion and NK cell activity in human ADAM17 deficiency

Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with a very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine secretion in response to LPS stimulation, correlating with the clinical picture of severe bacterem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tsukerman, Pinchas, Eisenstein, Eli M., Chavkin, Maor, Schmiedel, Dominik, Wong, Eitan, Werner, Marion, Yaacov, Barak, Averbuch, Diana, Molho-Pessach, Vered, Stepensky, Polina, Kaynan, Noa, Bar-On, Yotam, Seidel, Einat, Yamin, Rachel, Sagi, Irit, Elpeleg, Orly, Mandelboim, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792548/
https://ncbi.nlm.nih.gov/pubmed/26683521
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