Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

Senescent human diploid fibroblasts are unable to enter S phase in response to mitogenic stimulation. One of the key deficiencies in mitogen-stimulated senescent cells is their failure to phosphorylate the retinoblastoma protein, which acts as an inhibitor of entry into S phase in its unphosphorylat...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Dulić, V, Drullinger, L F, Lees, E, Reed, S I, Stein, G H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47916/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.11034
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