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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a poss...

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Autors principals: Alcorta, David A., Xiong, Yue, Phelps, Dawn, Hannon, Greg, Beach, David, Barrett, J. Carl
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1996
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19411/
https://ncbi.nlm.nih.gov/pubmed/8943005
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