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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a poss...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Alcorta, David A., Xiong, Yue, Phelps, Dawn, Hannon, Greg, Beach, David, Barrett, J. Carl
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19411/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943005/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13742
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