Inhibition of cyclin-dependent kinases by p21.

p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We have explored the interaction of p21 with the currently known Cdks. p21 effectively inhibits Cdk2, Cdk3, Cdk4, and Cdk6 kinases (Ki 0.5-15 nM) but is much less effective towa...

Full description

Saved in:

Bibliographic Details
Published in:	Mol Biol Cell
Main Authors:	Harper, J W, Elledge, S J, Keyomarsi, K, Dynlacht, B, Tsai, L H, Zhang, P, Dobrowolski, S, Bai, C, Connell-Crowley, L, Swindell, E
Format:	Artigo
Language:	Inglês
Published:	American Society for Cell Biology 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7626805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.6.4.387
Tags:	Add Tag No Tags, Be the first to tag this record!

Inhibition of cyclin-dependent kinases by p21.

Similar Items