Inhibition of cyclin-dependent kinases by p21.

p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We have explored the interaction of p21 with the currently known Cdks. p21 effectively inhibits Cdk2, Cdk3, Cdk4, and Cdk6 kinases (Ki 0.5-15 nM) but is much less effective towa...

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Hauptverfasser: Harper, J W, Elledge, S J, Keyomarsi, K, Dynlacht, B, Tsai, L H, Zhang, P, Dobrowolski, S, Bai, C, Connell-Crowley, L, Swindell, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC301199/
https://ncbi.nlm.nih.gov/pubmed/7626805
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