Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity

Amyotrophic lateral Sclerosis is characterized by progressive loss of motor neurons in the brain and spinal cord. Mutations in several genes, including FUS, TDP43, Matrin 3, hnRNPA2 and other RNA binding proteins, have been linked to ALS pathology. Recently, Pur-alpha a DNA/RNA binding protein was f...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Daigle, J Gavin, Krishnamurthy, Karthik, Ramesh, Nandini, Casci, Ian, Monaghan, John, McAvoy, Kevin, Godfrey, Earl W, Daniel, Dianne C., Johnson, Edward M., Monahan, Zach, Shewmaker, Frank, Pasinelli, Piera, Pandey, Udai Bhan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791193/
https://ncbi.nlm.nih.gov/pubmed/26728149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1530-0
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