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Structure of the toxic core of α-synuclein from invisible crystals

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson’s disease and other neurodegenerative pathologies. An 11-residue segment, which we term NACore, appears responsible for amyloid formation and cytotoxicity of α-synuclein. Here we report c...

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Библиографические подробности
Опубликовано в: :Nature
Главные авторы: Rodriguez, Jose A., Ivanova, Magdalena I., Sawaya, Michael R., Cascio, Duilio, Reyes, Francis, Shi, Dan, Sangwan, Smriti, Guenther, Elizabeth L., Johnson, Lisa M., Zhang, Meng, Jiang, Lin, Arbing, Mark A., Nannega, Brent, Hattne, Johan, Whitelegge, Julian, Brewster, Aaron S., Messerschmidt, Marc, Boutet, Sébastien, Sauter, Nicholas K., Gonen, Tamir, Eisenberg, David
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791177/
https://ncbi.nlm.nih.gov/pubmed/26352473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15368
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