Structure of the toxic core of α-synuclein from invisible crystals

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson’s disease and other neurodegenerative pathologies. An 11-residue segment, which we term NACore, appears responsible for amyloid formation and cytotoxicity of α-synuclein. Here we report c...

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Publicado no:Nature
Main Authors: Rodriguez, Jose A., Ivanova, Magdalena I., Sawaya, Michael R., Cascio, Duilio, Reyes, Francis, Shi, Dan, Sangwan, Smriti, Guenther, Elizabeth L., Johnson, Lisa M., Zhang, Meng, Jiang, Lin, Arbing, Mark A., Nannega, Brent, Hattne, Johan, Whitelegge, Julian, Brewster, Aaron S., Messerschmidt, Marc, Boutet, Sébastien, Sauter, Nicholas K., Gonen, Tamir, Eisenberg, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791177/
https://ncbi.nlm.nih.gov/pubmed/26352473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15368
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