Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum

BACKGROUND: Fine tuning of the Wnt/β-catenin signaling pathway is essential for the proper development and function of the liver. Aberrant activation of this pathway is observed in 20%-40% of hepatocellular carcinomas (HCC). Notum encodes a secreted Wnt deacylase that inhibits Wnt activity and there...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Canal, Frédéric, Charawi, Sara, Grimber, Gisèle, Houbron, Christophe, Drouet, Valérie, Colnot, Sabine, Terris, Benoit, Cavard, Catherine, Perret, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790944/
https://ncbi.nlm.nih.gov/pubmed/26974334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150997
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