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The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation

BACKGROUND & AIMS: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC). Our recent data revealed that HNF4α level was decreased in mouse and human HCCs with activated β-catenin...

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Bibliografische gegevens
Gepubliceerd in:Liver Int
Hoofdauteurs: Sartor, Chiara, Bachelot, Laura, Godard, Cécile, Lager, Franck, Renault, Gilles, Gonzalez, Frank J., Perret, Christine, Gougelet, Angélique, Colnot, Sabine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387933/
https://ncbi.nlm.nih.gov/pubmed/30721564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.14068
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