Structure and mechanism of activity-based inhibition of the EGF-Receptor by Mig6

Mig6 is a feedback inhibitor that directly binds, inhibits and drives internalization of ErbB-family receptors. Mig6 selectivity targets activated receptors. Here we find that the EGF receptor phosphorylates Mig6 on Tyr394, and that this phosphorylation is primed by prior phosphorylation of an adjac...

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Détails bibliographiques
Publié dans:Nat Struct Mol Biol
Auteurs principaux: Park, Eunyoung, Kim, Nayoung, Ficarro, Scott B., Zhang, Yi, Lee, Byung Il, Cho, Ahye, Kim, Kihong, Park, Angela K.J., Park, Woong-Yang, Murray, Bradley, Meyerson, Matthew, Beroukhim, Rameen, Marto, Jarrod A., Cho, Jeonghee, Eck, Michael J.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790445/
https://ncbi.nlm.nih.gov/pubmed/26280531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3074
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