MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma

Activating mutations in NRAS are frequent driver events in cutaneous melanoma. NRAS is a GTP-binding protein, whose most well-characterized downstream effector is RAF leading to activation of MEK-ERK1/2 signaling. While there are no FDA-approved targeted therapies for melanoma patients with a primar...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Invest Dermatol
Huvudupphovsmän: Vu, Ha Linh, Rosenbaum, Sheera, Capparelli, Claudia, Purwin, Timothy J., Davies, Michael A., Berger, Adam C., Aplin, Andrew E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789776/
https://ncbi.nlm.nih.gov/pubmed/26967478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2015.11.012
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk