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MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma
Activating mutations in NRAS are frequent driver events in cutaneous melanoma. NRAS is a GTP-binding protein, whose most well-characterized downstream effector is RAF leading to activation of MEK-ERK1/2 signaling. While there are no FDA-approved targeted therapies for melanoma patients with a primar...
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| Publicado no: | J Invest Dermatol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4789776/ https://ncbi.nlm.nih.gov/pubmed/26967478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2015.11.012 |
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