MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma

Activating mutations in NRAS are frequent driver events in cutaneous melanoma. NRAS is a GTP-binding protein, whose most well-characterized downstream effector is RAF leading to activation of MEK-ERK1/2 signaling. While there are no FDA-approved targeted therapies for melanoma patients with a primar...

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Bibliographische Detailangaben
Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Vu, Ha Linh, Rosenbaum, Sheera, Capparelli, Claudia, Purwin, Timothy J., Davies, Michael A., Berger, Adam C., Aplin, Andrew E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789776/
https://ncbi.nlm.nih.gov/pubmed/26967478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2015.11.012
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