Architecture of autoinhibited and active BRAF/MEK1/14-3-3 complexes

RAF family kinases are RAS-activated switches that initiate signaling through the MAP kinase cascade to control cellular proliferation, differentiation and survival(1–3). RAF activity is tightly regulated, and inappropriate activation is a frequent cause of cancer(4–6). At present, the structural ba...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B., Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A., Jeon, Hyesung, Eck, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014971/
https://ncbi.nlm.nih.gov/pubmed/31581174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1660-y
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