Discovery of G Protein-Biased EP2 Receptor Agonists

[Image: see text] To identify G protein-biased and highly subtype-selective EP2 receptor agonists, a series of bicyclic prostaglandin analogues were designed and synthesized. Structural hybridization of EP2/4 dual agonist 5 and prostacyclin analogue 6, followed by simplification of the ω chain enabl...

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Publicat a:ACS Med Chem Lett
Autors principals: Ogawa, Seiji, Watanabe, Toshihide, Sugimoto, Isamu, Moriyuki, Kazumi, Goto, Yoshikazu, Yamane, Shinsaku, Watanabe, Akio, Tsuboi, Kazuma, Kinoshita, Atsushi, Kigoshi, Hideo, Tani, Kousuke, Maruyama, Toru
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789666/
https://ncbi.nlm.nih.gov/pubmed/26985320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00455
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