Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists

[Image: see text] A novel series of prostaglandin analogues with a seven-membered ring scaffold was designed, synthesized, and evaluated for the functional activation of prostaglandin receptors to identify potent and subtype-selective FP and EP3 dual agonists. Starting from the prostacyclin derivati...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sugimoto, Isamu, Kambe, Tohru, Okino, Tomotaka, Obitsu, Tetsuo, Ohta, Nobukazu, Nishiyama, Taihei, Kinoshita, Akihiro, Fujimoto, Taku, Egashira, Hiromu, Yamane, Shinsaku, Shuto, Satoshi, Tani, Kousuke, Maruyama, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238478/
https://ncbi.nlm.nih.gov/pubmed/28105284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00415
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