Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

BACKGROUND: Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 inhibitor...

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Vydáno v:J Hematol Oncol
Hlavní autoři: Feng, Zizhen, Yao, Yuan, Zhou, Chao, Chen, Fengju, Wu, Fangrui, Wei, Liping, Liu, Wei, Dong, Shuo, Redell, Michele, Mo, Qianxing, Song, Yongcheng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789278/
https://ncbi.nlm.nih.gov/pubmed/26970896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0252-7
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