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Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability
Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked to culture density is the main cause of DNA damage...
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| Опубликовано в: : | Stem Cell Reports |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4788786/ https://ncbi.nlm.nih.gov/pubmed/26923824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.01.015 |
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