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Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability

Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked to culture density is the main cause of DNA damage...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Stem Cell Reports
मुख्य लेखकों: Jacobs, Kurt, Zambelli, Filippo, Mertzanidou, Afroditi, Smolders, Ilse, Geens, Mieke, Nguyen, Ha Thi, Barbé, Lise, Sermon, Karen, Spits, Claudia
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788786/
https://ncbi.nlm.nih.gov/pubmed/26923824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.01.015
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