Enhanced Hepatotoxicity by Acetaminophen in Vanin-1 Knockout Mice is Associated with Deficient Proliferative and Immune Responses

BACKGROUND AND AIMS: Pretreatment with clofibrate, a peroxisome proliferator-activated receptor alpha (PPARa) agonist, protects mice from acetaminophen (APAP) injury. Protection is not due to alterations in APAP metabolism and is dependent on PPARa expression. Gene array analysis revealed that mice...

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Xehetasun bibliografikoak
Argitaratua izan da:Biochim Biophys Acta
Egile Nagusiak: Ferreira, Daniel W., Goedken, Michael J., Rommelaere, Samuel, Chasson, Lionel, Galland, Franck, Naquet, Philippe, Manautou, José E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788548/
https://ncbi.nlm.nih.gov/pubmed/26850476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.02.001
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