5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

5-Lipoxygenase (5-LO) converts arachidonic acid into leukotrienes (LTs) and is involved in inflammation. At present, the participation of 5-LO in acetaminophen (APAP)-induced hepatotoxicity and liver damage has not been addressed. 5-LO deficient (5-LO(−/−)) mice and background wild type mice were ch...

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Autors principals: Hohmann, Miriam S. N., Cardoso, Renato D. R., Pinho-Ribeiro, Felipe A., Crespigio, Jefferson, Cunha, Thiago M., Alves-Filho, José C., da Silva, Rosiane V., Pinge-Filho, Phileno, Ferreira, Sergio H., Cunha, Fernando Q., Casagrande, Rubia, Verri, Waldiceu A.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832964/
https://ncbi.nlm.nih.gov/pubmed/24288682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/627046
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