Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18

Activators of innate immunity may have the potential to combat a broad range of infectious agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice. Protection was independent of adaptive immunity and interferon (IFN,...

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Опубликовано в: :Science
Главные авторы: Zhang, Benyue, Chassaing, Benoit, Shi, Zhenda, Uchiyama, Robin, Zhang, Zhan, Denning, Timothy L., Crawford, Sue E., Pruijssers, Andrea J., Iskarpatyoti, Jason A., Estes, Mary K., Dermody, Terence S., Ouyang, Wenjun, Williams, Ifor R., Vijay-Kumar, Matam, Gewirtz, Andrew T.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788408/
https://ncbi.nlm.nih.gov/pubmed/25395539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1256999
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