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IL-22 induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus infection

Bacterial flagellin can elicit production of TLR5-mediated IL-22 and NLRC4-mediated IL-18, cytokines that act in concert to cure and prevent rotavirus (RV) infection. This study investigated the mechanism by which these cytokines act to impede RV. Although IL-18 and IL-22 induce each other’s express...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Zhang, Zhan, Zou, Jun, Shi, Zhenda, Zhang, Benyue, Etienne-Mesmin, Lucie, Wang, Yanling, Shi, Xuyan, Shao, Feng, Chassaing, Benoit, Gewirtz, Andrew T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709835/
https://ncbi.nlm.nih.gov/pubmed/33008915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd2876
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