Mechanism of Lithium Diisopropylamide-Mediated Ortholithiation of 1,4-bis(Trifluoromethyl)benzene under Nonequilibrium Conditions: Condition-Dependent Rate Limitation and Lithium Chloride-Catalyzed Inhibition

Lithiation of 1,4-bis(trifluoromethyl)benzene with lithium diisopropylamide (LDA) in tetrahydrofuran at −78 °C occurs under conditions in which the rates of aggregate exchanges are comparable to the rates of metalation. Under such nonequilibrium conditions, a substantial number of barriers compete t...

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Publicado en:J Am Chem Soc
Main Authors: Liang, Jun, Hoepker, Alexander C., Algera, Russell F., Ma, Yun, Collum, David B.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788392/
https://ncbi.nlm.nih.gov/pubmed/25900574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01668
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