Regioselective Lithium Diisopropylamide-Mediated Ortholithiation of 1-Chloro-3-(trifluoromethyl)benzene: Role of Autocatalysis, Lithium Chloride Catalysis, and Reversibility

Ortholithiation of 1-chloro-3-(trifluoromethyl)benzene with lithium diisopropylamide (LDA) in tetrahydrofuran at −78 °C displays characteristics of reactions in which aggregation events are rate limiting. Metalation with lithium chloride-free LDA involves a rate-limiting deaggregation via dimer-base...

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Huvudupphovsmän: Hoepker, Alexander C., Gupta, Lekha, Ma, Yun, Faggin, Marc F., Collum, David B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102585/
https://ncbi.nlm.nih.gov/pubmed/21500823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200906z
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