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Lithium Diisopropylamide-Mediated Ortholithiation of 2–Fluoropyridines: Rates, Mechanisms, and the Role of Autocatalysis

Lithium diisopropylamide (LDA)-mediated ortholithiations of 2–fluoropyridine and 2,6–difluoropyridine in tetrahydrofuran at −78 °C were studied using a combination of IR and NMR spectroscopic and computational methods. Rate studies show that a substrate-assisted deaggregation of LDA dimer occurs par...

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Detaylı Bibliyografya
Asıl Yazarlar: Gupta, Lekha, Hoepker, Alexander C., Ma, Yun, Viciu, Mihai S., Faggin, Marc F., Collum, David B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644364/
https://ncbi.nlm.nih.gov/pubmed/23270408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo302408r
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