Structural basis for DNA strand separation by a hexameric replicative helicase

Hexameric helicases are processive DNA unwinding machines but how they engage with a replication fork during unwinding is unknown. Using electron microscopy and single particle analysis we determined structures of the intact hexameric helicase E1 from papillomavirus and two complexes of E1 bound to...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Chaban, Yuriy, Stead, Jonathan A., Ryzhenkova, Ksenia, Whelan, Fiona, Lamber, Ekaterina P., Antson, Alfred, Sanders, Cyril M., Orlova, Elena V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787811/
https://ncbi.nlm.nih.gov/pubmed/26240379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv778
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