A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding

The mechanism of DNA translocation by papillomavirus E1 and polyomavirus LTag hexameric helicases involves consecutive remodelling of subunit–subunit interactions around the hexameric ring. Our biochemical analysis of E1 helicase demonstrates that a 26-residue C-terminal segment is critical for main...

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Autors principals: Whelan, Fiona, Stead, Jonathan A., Shkumatov, Alexander V., Svergun, Dmitri I., Sanders, Cyril M., Antson, Alfred A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3300016/
https://ncbi.nlm.nih.gov/pubmed/22067453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr906
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