Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor Beta Induced Protein (TGFBIp) in Corneal Dystrophies Compared to the Non-Fibrillating R555W and R555Q Mutants

The human transforming growth factor beta induced protein (TGFBIp) is involved in several types of corneal dystrophies where protein aggregation and amyloid fibril formation severely impairs vision. Most disease-causing mutations are located in the last of four homologous fasciclin-1 (FAS1) domains...

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Publicat a:Biochemistry
Autors principals: Koldsø, Heidi, Andersen, Ole Juul, Nikolajsen, Camilla Lund, Scavenius, Carsten, Sørensen, Charlotte S., Underhaug, Jarl, Runager, Kasper, Nielsen, Niels Chr., Enghild, Jan J., Schiøtt, Birgit
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787542/
https://ncbi.nlm.nih.gov/pubmed/26305369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00473
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