Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor Beta Induced Protein (TGFBIp) in Corneal Dystrophies Compared to the Non-Fibrillating R555W and R555Q Mutants

The human transforming growth factor beta induced protein (TGFBIp) is involved in several types of corneal dystrophies where protein aggregation and amyloid fibril formation severely impairs vision. Most disease-causing mutations are located in the last of four homologous fasciclin-1 (FAS1) domains...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Koldsø, Heidi, Andersen, Ole Juul, Nikolajsen, Camilla Lund, Scavenius, Carsten, Sørensen, Charlotte S., Underhaug, Jarl, Runager, Kasper, Nielsen, Niels Chr., Enghild, Jan J., Schiøtt, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787542/
https://ncbi.nlm.nih.gov/pubmed/26305369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00473
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