Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor Beta Induced Protein (TGFBIp) in Corneal Dystrophies Compared to the Non-Fibrillating R555W and R555Q Mutants

The human transforming growth factor beta induced protein (TGFBIp) is involved in several types of corneal dystrophies where protein aggregation and amyloid fibril formation severely impairs vision. Most disease-causing mutations are located in the last of four homologous fasciclin-1 (FAS1) domains...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Koldsø, Heidi, Andersen, Ole Juul, Nikolajsen, Camilla Lund, Scavenius, Carsten, Sørensen, Charlotte S., Underhaug, Jarl, Runager, Kasper, Nielsen, Niels Chr., Enghild, Jan J., Schiøtt, Birgit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787542/
https://ncbi.nlm.nih.gov/pubmed/26305369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00473
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg