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Polymorphic Fibrillation of the Destabilized Fourth Fasciclin-1 Domain Mutant A546T of the Transforming Growth Factor-β-induced Protein (TGFBIp) Occurs through Multiple Pathways with Different Oligomeric Intermediates

Mutations in the transforming growth factor β-induced protein (TGFBIp) are linked to the development of corneal dystrophies in which abnormal protein deposition in the cornea leads to a loss of corneal transparency and ultimately blindness. Different mutations give rise to phenotypically distinct co...

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Main Authors: Andreasen, Maria, Nielsen, Søren B., Runager, Kasper, Christiansen, Gunna, Nielsen, Niels Chr., Enghild, Jan J., Otzen, Daniel E.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464576/
https://ncbi.nlm.nih.gov/pubmed/22893702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.379552
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