Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1

Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment. Using a combination of biophysical techniques, in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Rubio-Marrero, Eva N., Vincelli, Gabriele, Jeffries, Cy M., Shaikh, Tanvir R., Pakos, Irene S., Ranaivoson, Fanomezana M., von Daake, Sventja, Demeler, Borries, De Jaco, Antonella, Perkins, Guy, Ellisman, Mark H., Trewhella, Jill, Comoletti, Davide
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786715/
https://ncbi.nlm.nih.gov/pubmed/26721881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705681
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