Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1

Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment. Using a combination of biophysical techniques, in...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Rubio-Marrero, Eva N., Vincelli, Gabriele, Jeffries, Cy M., Shaikh, Tanvir R., Pakos, Irene S., Ranaivoson, Fanomezana M., von Daake, Sventja, Demeler, Borries, De Jaco, Antonella, Perkins, Guy, Ellisman, Mark H., Trewhella, Jill, Comoletti, Davide
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786715/
https://ncbi.nlm.nih.gov/pubmed/26721881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705681
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