Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1

Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment. Using a combination of biophysical techniques, in...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Rubio-Marrero, Eva N., Vincelli, Gabriele, Jeffries, Cy M., Shaikh, Tanvir R., Pakos, Irene S., Ranaivoson, Fanomezana M., von Daake, Sventja, Demeler, Borries, De Jaco, Antonella, Perkins, Guy, Ellisman, Mark H., Trewhella, Jill, Comoletti, Davide
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786715/
https://ncbi.nlm.nih.gov/pubmed/26721881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705681
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