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The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

Dnmt1 is critical for immediate postnatal intestinal development, but is not required for the survival of the adult intestinal epithelium, the only rapidly dividing somatic tissue for which this has been shown. Acute Dnmt1 deletion elicits dramatic hypomethylation and genomic instability. Recovery o...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Elliott, Ellen N, Sheaffer, Karyn L, Kaestner, Klaus H
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786433/
https://ncbi.nlm.nih.gov/pubmed/26808831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12975
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